Did you look at the link? Do the Lapierre Enduro bike or Look gravel bike look any different than any others?
The weight penalty for an e-capable frame will be so minimal as to not matter unless you are talking about a 15lb road weenie. The frame will be built such that the internal supporting structures for the battery and motor will slide in. The BB will be different depending on whether you need a geared BB spindle or not.
Yes, of course, we are talking about internal drivetrains, like the Fazua.
Go back to the link and tell us about the compromises on the Lapierre and the Look.
Oh, and all the Luddites should love the bit about the new Fox electronic damping systems. Soon you will have a motor for shifting, a motor for damping, and a motor for assist. Batteries for all of the above, plus lights and computer. I'm guessing eventually some company will produce a single battery system designed to power *all* of the electronics: shifting, damping, bike computer, lights, and anything else, and probably a cool generator system that works on a regen basis or even on motion recovery. It is easy to imagine an electronic damper than can generate power for its internal battery from the motion of the shock.
eBikes already have a huge battery available to run everything. Bosch-assist bikes can already have integrated lights that run off of the main battery, and some models have a USB charging port. I believe the Shimano eSteps motor system also powers the Di2 shifting if it is onboard.